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Senior Fellow

Dietlind Gerloff

Education and Work

  • MS in Chemistry, Swiss Federal Institute of Technology (ETH) Zurich
  • PhD in Chemistry, Swiss Federal Institute of Technology (ETH) Zurich
  • Postdoc in Computational Biology, UC San Francisco
  • Lecturer in Bioinformatics, University of Edinburgh UK (1999-2006)
  • Asst Professor, Biomolecular Engineering, UC Santa Cruz (2007-2013)
  • Senior Fellow, FfAME (2013-present)

Research summary

My group is developing novel approaches to facilitate research in all areas of modern biology by working at the interface between information technology and engineering, structural biochemistry, evolutionary biology, and experimental molecular biology. Particularly the molecular understanding of biomolecular interactions, and our ability to predict them from sequence can provide helpful clues toward resolving a variety of important scientific issues, from evolutionary mechanisms to experimental design in functional genomics. Our specific research projects often begin with collaborations with a lab facing a particular data challenge, or simply wanting to find out more about their favorite gene/protein/species.

Our collaborations, and our pursuit of the topic beyond this, have created a varied research portfolio over the years. Find our most recent publications, and as their authors the resourceful students and colleagues who made them possible. We also maintain three web-based resources:


A list of recent publications is below. For a more complete list, please visit this collection on PubMed.

Recent Publications


Polymerase Interactions with Wobble Mismatches in Synthetic Genetic Systems and Their Evolutionary Implications
Christian B. Winiger, Myong-Jung Kim, Shuichi Hoshika, Ryan W. Shaw, Jennifer D. Moses, Mariko F. Matsuura, Dietlind L. Gerloff, and Steven A. Benner
Biochemistry 55 (28) 3847-3850 (2016) DOI: 10.1021/acs.biochem.6b00533


Evolution of functional six-nucleotide DNA
Zhang, L., Yang, Z., Sefah, K., Bradley, K. M., Hoshika, S., Kim, M-J,. Kim, H-J., Zhu., Jimenez, E., Cansiz, S., Teng, I-T., Champanhac, C, McLendon, C., Liu, C., Zhang, W., Gerloff, D. L., Huang, Z., Tan, W., Benner, S. A.
J. Am. Chem. Soc. (2015) DOI: 10.1021/jacs.5b02251


Pooled assembly of marine metagenomic datasets: enriching annotation through chimerism
Jonathan D. Magasin and Dietlind L. Gerloff
Bioinformatics (2015) 31:311-317


3D topology of the SMC2/SMC4 sub-complex from chicken condensin I revealed by cross-linking and molecular modeling
Barysz H, Kim JH, Chen ZA, Hudson DF, Rappsilber J, Gerloff DL, Earnshaw WC
Open Biology , The Royal Society Publishing (2015) 5:150005


Protein Domains of Unknown Function Are Essential in Bacteria
Norman F. Goodacre, Dietlind L. Gerloff, Peter Uetz
mBio , American Society for Microbiology (2014) 5(1):e00744-13


MaGnET: Malaria Genome Exploration Tool
Sharman JL and Gerloff DL
Bioinformatics (2013) 2350-2352

(View publication page for Dietlind Gerloff)

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